The Effects Of Fresh And Thermoxidized Palm Oil Diets On Some Haematological Indices In The Rat

The effects of fresh and thermoxidized palm oil diets on some haematalogical indices in the rat were investigated in albino rats (Wistar strain). The animals were divided into three groups namely, the first group fed on thermoxidized palm oil (TPO) diet, a second group fed on fresh palm oil (FPO) diet and a third fed on normal rat feed (control) only respectively for 14 weeks. Each of the palm oil diets contained 15% (w/w) thermoxidized or fresh palm oil. The packed cell volume (PCV) of the TPO group (44.87 ± 0.8%) was significantly (P < 0.001) lower than that of the FPO group (52.50 ± 0.4%) and control group (54.75 ± 1.3%). The haemoglobin (Hb) concentration of the TPO group (11.66 ± 0.8g/dl) was significantly (P < 0.001) lower than that of control group (13.14 ± 0.4g/dl) and the FPO group (12.88 ± 0.8g/dl). The red cell count (RBC) of the TPO group (6.06 x 106 ± 0.4 x 106 per mm3 of blood) was significantly (P < 0.001) lower than that of control group (7.28 x 106 ± 0.4 x 106 per mm3 of blood) and the FPO group (7.19 x 106 ± 0.2 x 106 per mm3 of blood). The white blood cell count (WBC) of the TPO group (3.42 x 103 ± 0.1 x 103 per mm3 of blood) was significantly (p< 0.001) higher than that of control group (2.39 x 103 ± 0.1 x 10 per mm3 of blood) and FPO group (2.51 x 103 ± 0.1 x 103 per mm3 of blood). There were no significant differences between the heamatological indices of the fresh palm oil (FPO) and control groups. Our results suggest that chronic consumption of thermoxidized palm oil diet may result in anaemia and leucocytosis in the rat. Key words: Fresh palm oil; Thermoxidized palm oil; RBC; WBC; Hb; PCV. Nigerian Journal of Physiological Sciences Vol.19(1&2) 2004: 86-9

Morphometric Study Of The Teratogenic Effect Of Artesunate On The Central Nervous System Of The Wistar Rat Foetus

The teratogenic influence of maternal administration of artesunate on the morphometry of foetal nervous system was studied. Twenty virgin female Wistar rats weighing between 200g and 230g were used for this study. The animals were divided into 4 groups of 5 rats each. Each group was kept in a separate plastic cage. The rats were fed with commercial rat feed and tap water ad libitum throughout the experimental period. The females were caged overnight with sexually mature male rats of the same strain. The presence of sperm (tailed structures) in the vagina smears obtained the following morning confirmed coitus and the sperm positive day was designated as day zero of pregnancy. Oral doses of 0.2mg/kg, 0.4mg/kg and 0.8mg/kg body weight of artesunate were administered to pregnant rats in 3 of the groups respectively from the 7th to the 11th day of gestation. The fourth group of rats was used as the control which received 2.0ml/kg body weight of distilled water on the same days. Results show that the high dose group rats demonstrated significant (

Sperm Quality and Fertility Following Prolonged Immobilization Stress in Wistar Rats

Abstract: Sperm quality and fertility following prolonged immobilization stress in Wistar rats was studied. Twenty adult albino wistar rats randomly divided into 2 groups (A and B) of 10 rats each were used. Group A served as control while group B rats were immobilized for 4 hour a day for 2 months. All the females that were mated with the control males became pregnant and produced litters. On the other hand, none of the females that were mated with the immobilized males got pregnant. There was also a significant difference (

Modulatory Effect of Vitamin C and E on Dihydroartemisinin (Cotecxin) Induced Hepatotoxicity in Wistar Albino Rats

Abstract: The modulatory effect of vitamin C and E supplementation during dihydroartemisinin administration on the body weight and serum liver enzymes in wistar albino rats investigated. Thirty two adult albino rats weighing between 180 – 260g were used. There were divided into four groups of eight rats each. Group A served as the control and was administereddistilled water. Groups B, C and D, were the experimental groups and were given cotecxin + vitamin A and cotecxin + vitamin E respectively for two weeks. The animals were weighed at the beginning and at the end of the experiment; water and feed were allowed ad libitum. In all the parameters estimated, there were significant differences at

Influence of thermoxidized and fresh palm oil diets on some mineral contents of the femur bone of growing Wistar Rats

No Abstract Available J. Expt. & Clin. Anat Vol.3(1) 2004:8-1

Influence of Chronic Consumption of Fresh and Thermoxidzed Palm Oil Diets on Sperm Count and Sperm Motility in Wister Rats

The influence of chronic consumption of fresh and thermoxidized plam oil diets on sperm count and motility was studied in rats. Thirty young Wister rats initially weighing between 50-65g were randomly divided into 3 group, (A,B and C) of ten rats each. Group A rats were fed thermoxidized palm oil diet, obtained by mixing 15g of thermoxidized palm oil with 85g of rat feed (15% w/w). Group B rats were fed fresh palm oil diet, obtained by mixing 15g of fresh palm oil with 85g of rat feed (15% w/w). Group C rats served as control and were allowed fed normal rat fed. The animals were allowed the test diets and water ad libitum for 20 weeks. Results obtained showed that there was a significant difference (

Effects of maternal administation of Bonny light crude oil on brain dimensions of wistar rat foetuses

No Abstract.Global Journal of Pure and Applied Sciences Vol. 13 (1) 2007: pp. 95-9

Teratogenic effect of maternal administration of aloe vera extract on foetal morphology and the histology of the foetal kidney

No Abstract. Global Journal of Medical Sciences Vol. 5(1) 2006: 41-4

Effects of bonny light crude oil on the morphology of litters of wistar rats

No Abstract. Global Journal of Medical Sciences Vol. 5(1) 2006: 51-5

Haematological changes following vitamin E supplementation during caffeinated and non-caffeinated paracetamol administration in rats

No Abstract. Journal of Experimental and Clinical Anatomy Vol. 4(2) 2005: 52-5